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Challenges and opportunities in improving left ventricular remodelling and clinical outcome following surgical and trans-catheter aortic valve replacement

《医学前沿（英文）》 2021年 第15卷 第3期   页码 416-437 doi: 10.1007/s11684-021-0852-7

摘要： Over the last half century, surgical aortic valve replacement (SAVR) has evolved to offer a durable and efficient valve haemodynamically, with low procedural complications that allows favourable remodelling of left ventricular (LV) structure and function. The latter has become more challenging among elderly patients, particularly following trans-catheter aortic valve implantation (TAVI). Precise understanding of myocardial adaptation to pressure and volume overloading and its responses to valve surgery requires comprehensive assessments from aortic valve energy loss, valvular-vascular impedance to myocardial activation, force-velocity relationship, and myocardial strain. LV hypertrophy and myocardial fibrosis remains as the structural and morphological focus in this endeavour. Early intervention in asymptomatic aortic stenosis or regurgitation along with individualised management of hypertension and atrial fibrillation is likely to improve patient outcome. Physiological pacing via the His-Purkinje system for conduction abnormalities, further reduction in para-valvular aortic regurgitation along with therapy of angiotensin receptor blockade will improve patient outcome by facilitating hypertrophy regression, LV coordinate contraction, and global vascular function. TAVI leaflet thromboses require anticoagulation while impaired access to coronary ostia risks future TAVI-in-TAVI or coronary interventions. Until comparable long-term durability and the resolution of TAVI related complications become available, SAVR remains the first choice for lower risk younger patients.

关键词： surgical aortic valve replacement     trans-catheter aortic valve implantation     left ventricular hypertrophy and fibrosis     myocardial force-velocity relationship     His-Purkinje pacing     renin-angiotensin system inhibitors     coronary access impairment    

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Study on damping properties of magnetorheological damper

ZHOU Yu-feng, CHEN Hua-ling

《机械工程前沿（英文）》 2006年 第1卷 第4期   页码 452-455 doi: 10.1007/s11465-006-0057-4

摘要： To research the properties of a new kind of smart controllable MR (magnetorheological) fluid, in this paper, the rheological models are discussed. On the basis of analyzing the structural forms of MR dampers, an improved structure of the MR damper is introduced; the properties of the novel MR damper are then tested. The experimental results reveal that the Herschel-Bulkley model predicts the force-velocity well; the damping properties of the ameliorated structure of the MR damper have improved; when the excitation is a trigonal signal, the MR damper reveals a thinning effect at high velocity; and when the excitation is a sinusoidal signal, the MR damper reveals a nonlinear hysteretic property between the damping force and relative velocity. Finally, the main unsolved problems have been put forward.

关键词： nonlinear hysteretic     force-velocity     unsolved     excitation     magnetorheological    

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Berberine alleviates myocardial diastolic dysfunction by modulating Drp1-mediated mitochondrial fission

《医学前沿（英文）》 doi: 10.1007/s11684-023-0983-0

摘要： Berberine alleviates myocardial diastolic dysfunction by modulating Drp1-mediated mitochondrial fission and Ca homeostasis in a murine model of HFpEF

关键词： mitochondrial fission Ca     Berberine alleviates myocardial     murine model HFpEF    

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Evaluation of the effect of myocardial perfusion after percutaneous coronary intervention in coronaryartery disease by using intracoronary myocardial contrast echocardiography and two other angiographic

WANG Hong, HUANG Lan, JIN Jun, SONG Yaoming, GENG Zhaohua, YU Xuejun, QIN Jun, ZHAO Gang, GAO Yunhua, LIU Zheng

《医学前沿（英文）》 2007年 第1卷 第1期   页码 62-67 doi: 10.1007/s11684-007-0013-7

摘要： Detection of abnormal myocardial perfusion is crucial to the prognosis of patients with coronary artery disease (CAD) after they have undergone percutaneous coronary intervention (PCI). The objective of this study is to evaluate the effect of myocardial perfusion by three different methods intra-coronary myocardial contrast echocardiography (ICMCE), corrected thrombolysis in myocardial infarction frame count (CTFC), and coronary blood flow velocity (BFV) and to determine the value of these different methods in the evaluation of the effect of myocardial perfusion post-PCI. For the study sixty-eight patients were divided into four groups based on selective coronary angiography results: group A (normal coronary artery), group B (75% 95% coronary artery stenosis), group C (coronary artery stenosis >95%) and group D (acute total coronary occlusion). The effect of myocardial reperfusion was evaluated using the above mentioned three methods 15 min after PCI. IC-MCE was also performed before PCI in group D. The quantitative parameters of MCE involved: contrast peak intensity, time to peak intensity and area under the curve, representing myocardial blood volume, reperfusion velocity and myocardial blood flow, respectively. No difference was found in CTFC between the coronary artery stenosis group and the normal group. BFV was slower in group D than in group A (<0.05). The myocardial blood volume and the myocardial blood flow of the IC-MCE quantitative parameters were markedly lower in group C compared with those in group A (<0.05), and there were significant differences in the three MCE parameters between group D and group A (<0.05). For those patients with acute or total occlusion, the levels of myocardial perfusion before and after PCI were similar, as determined by IC-MCE and visually analyzed from 61 segments (<0.05). Quantitative IC-MCE evaluation of myocardial reperfusion is more accurate than with the other two methods. Moreover, with qualitative IC-MCE the level of myocardial reperfusion can be viewed directly and rapidly. Thus, the IC-MCE method is of great value to coronary artery disease (CAD) patients undergoing PCI, especially for those with acute myocardial infarction (AMI).
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Three-dimensional numerical simulation of flow in trapezoidal cutthroat flumes based on FLOW-3D

Danjie RAN, Wene WANG, Xiaotao HU

《农业科学与工程前沿（英文）》 2018年 第5卷 第2期   页码 168-176 doi: 10.15302/J-FASE-2018217

摘要： To solve the common problem of flumes flow-measurement accuracy without sacrificing water head, a new type of trapezoidal cutthroat flume to measure the discharge in terminal trapezoidal channels is presented. Using the computational fluid dynamic method, three-dimensional flow fields in trapezoidal cutthroat flumes were simulated using the RNG three-dimensional turbulence model along with the TruVOF technique. Simulations were performed for 12 working conditions, with discharges up to 0.075 m ·s to determine hydraulic performance. Experimental data for the trapezoidal cutthroat flume in terminal trapezoidal channel were also obtained to validate the simulation results. Velocity distribution of the flume obtained from simulation analyses were compared with observed results based on time-averaged flow field and comparison yielded a solid agreement between results from the two methods, with relative error below 10%. The results indicated that the Froude number and the longitudinal average velocity increased along the convergence section and decreased in the divergent section. In the upper throat, the Froude number was less than 0.5, which meets the water measurement requirement, and the critical flow appeared near the throat section. The maximum water head loss of the trapezoidal cutthroat flume was less than 9% of the total head, compared to the rectangular cutthroat flume, and head loss of trapezoidal cutthroat flume was significantly less. Regression models developed for upstream depth versus discharge under different working conditions were satisfactory, with a relative error of less than 2.06%, which meets the common requirements of flow measurement in irrigation areas. It was concluded that trapezoidal cutthroat flumes can improve flow-measurement accuracy without sacrificing water head.

关键词： distribution of velocity     Froude number     head loss     stage-discharge relationship     trapezoidal cutthroat flume    

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failure and left ventricular systolic dysfunction in non-diabetic patients with ST-segment elevation myocardial

Hui Wang, Yang Zhang, Zhujun Shen, Ligang Fang, Zhenyu Liu, Shuyang Zhang

《医学前沿（英文）》 2021年 第15卷 第1期   页码 70-78 doi: 10.1007/s11684-020-0749-x

摘要： Recent studies have shown that acute blood glucose elevation in patients with ST-segment elevation myocardial infarction (STEMI) suggests a poor prognosis. To investigate the effect of fasting blood glucose (FBG) on the risk of heart failure (HF) and left ventricular systolic dysfunction (LVSD) in non-diabetic patients undergoing primary percutaneous coronary intervention (PCI) for acute STEMI, we retrospectively recruited consecutive non-diabetic patients who underwent primary PCI for STEMI in our hospital from February 2003 to March 2015. The patients were divided into two groups according to the FBG level. A total of 623 patients were recruited with an age of 61.3±12.9 years, of whom 514 (82.5%) were male. The HF risk (odds ratio 3.401, 95% confidence interval (CI) 2.144–5.395, <0.001) was significantly increased in patients with elevated FBG than those with normal FBG. Elevated FBG was also independently related to LVSD (β 1.513, 95%CI 1.282–1.785, <0.001) in a multiple logistics regression analysis. In conclusion, elevated FBG was independently associated with 30-day HF and LVSD risk in non-diabetic patients undergoing primary PCI for STEMI.

关键词： myocardial infarction     percutaneous coronary intervention     diabetes mellitus     fasting glucose     heart failure    

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柱形地形上单浮体的辐射和散射问题

吴必军,郑永红,游亚戈,孙晓燕,陈勇

《中国工程科学》 2004年 第6卷 第2期   页码 48-55

摘要：

在有限水深、同轴但半径大于或等于浮体半径的圆柱体障碍物地形条件下，基于特征函数展开法，推导了垂直放置的圆柱形浮体由于波的辐射和散射作用所表现的动力学和运动学特征表达式，涉及浮体做垂荡、横荡和横摇运动所产生的辐射势，以及在入射波的作用下，由于浮体固定不动而产生的散射势，并推导了激励力、附加质量和阻尼系数表达式。采用与同轴、同半径圆柱体障碍物地形上单浮体水动力学特性相比的方式和激励力计算两种方法验证了推导的表达式，最后分析了障碍物几何尺寸对浮体水动力学特性的特有影响。

关键词： 解析方法     速度势     波浪力    

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Protective effect of tanshinone II A on signal transduction system protein kinase B in rats with myocardial

Enyuan TU MD, Yongjun PAN MM, Kang ZHENG MM, Zhaohua WANG MD, Qiansheng LIANG MD, Guangtian YANG MD,

《医学前沿（英文）》 2009年 第3卷 第4期   页码 431-436 doi: 10.1007/s11684-009-0088-4

摘要： The effects of tanshinone II A on cell signal transduction system protein kinase B in rats with myocardial hypertrophy induced by the abdominal aorta partial coarctation were investigated. Rat models of myocardial hypertrophy were established by using abdominal aorta partial coarctation method. Forty-eight rats were randomly divided into sham group (S group), model group (M group), valsartan treatment group (X group), low-dose tanshinone treatment group (LD group), medium-dose tanshinone treatment group (MD group), and high-dose tanshinone treatment group (HD group) (=8 in each group). Left ventricular mass index (LVMI), left ventricular posterior wall (LVPW), and septal thickness (IVS) were detected by high frequency ultrasonography. Myocardial fiber diameter (MFD) was examined by Hematoxylin-Eosin (HE) staining, and the contents of phosphorylated protein kinase B (p-Akt) and p-Gsk3β in myocardium were assayed by Western blot. The results showed that compared with S group, the values of LVMI, LVPW, IVS and MFD were increased in other groups (<0.05), and the contents of p-Akt, and p-Gsk3β were also increased in other groups. As compared with MD group, the values of LVMI, LVPW, IVS and MFD were decreased in all treatment groups (<0.05), and the contents of p-Akt, and p-Gsk3β were also decreased in all treatment groups. However, there were no significant differences among LD, MD, and HD groups (>0.05), and there were no significant differences between X group and tanshinone treatment groups (>0.05). It was suggested that tanshinone II A could prevent myocardial hypertrophy by its action on the Akt signaling pathway.

关键词： tanshinone II A     myocardial hypertrophy     rat     protein kinase B     abdominal aorta coarctation    

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Prediction of the shear wave velocity

Amoroso SARA

《结构与土木工程前沿（英文）》 2014年 第8卷 第1期   页码 83-92 doi: 10.1007/s11709-013-0234-6

摘要： The paper examines the correlations to obtain rough estimates of the shear wave velocity from non-seismic dilatometer tests (DMT) and cone penetration tests (CPT). While the direct measurement of is obviously preferable, these correlations may turn out useful in various circumstances. The experimental results at six international research sites suggest that the DMT predictions of from the parameters (material index), (horizontal stress index), (constrained modulus) are more reliable and consistent than the CPT predictions from (cone resistance), presumably because of the availability, by DMT, of the stress history index .

关键词： horizontal stress index     shear wave velocity     flat dilatometer test     cone penetration test    

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Modeling limit force capacities of high force to volume lead extrusion dampers

《结构与土木工程前沿（英文）》 2021年 第15卷 第3期   页码 609-622 doi: 10.1007/s11709-021-0724-x

摘要： Lead extrusion dampers are supplemental energy-dissipation devices that are used to mitigate seismic structural damage. Small volumetric sizes and high force capacities define high-force-to-volume (HF2V) devices, which can absorb significant response energy without sacrificial damage. However, the design of such devices for specific force capacities has proven difficult based on the complexities of their internal reaction mechanisms, leading to the adoption of empirical approaches. This study developed upper- and lower-bound force capacity estimates from analytical mechanics based on direct and indirect metal extrusion for guiding design. The derived equations are strictly functions of HF2V device geometric parameters, lead material properties, and extrusion mechanics. The upper-bound estimates from direct and indirect extrusion are denoted as (FUB,1, FUB,2) and (FUB,3, FUB,4), respectively, and the lower-bound estimates are denoted as (FLB, FLB,1) based on the combination of extrusion and friction forces. The proposed models were validated by comparing the predicted bounds to experimental force capacity data from 15 experimental HF2V device tests. The experimental device forces all lie above the lower-bound estimates (FLB, FLB,1) and below the upper-bound estimates (FUB,1, FUB,2, FUB,4). Overall, the (FLB, FUB,2) pair provides wider bounds and the (FLB,1, FUB,4/FUB,1) pair provides narrower bounds. The (FLB,1, FUB,1) pair has a mean lower-bound gap of 36%, meaning the lower bound was 74% of the actual device force on average. The mean upper-bound gap was 33%. The bulge area and cylinder diameter of HF2V devices are key parameters affecting device forces. These relatively tight bounds provide useful mechanics-based predictive design guides for ensuring that device forces are within the targeted design range after manufacturing.

关键词： extrusion     lead dampers     upper and lower bound     analytical modelling     limit force    

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Influence of retinoic acid on TBX1 expression in myocardial cells induced by Shh and Fgf8

Miao LIU, Xiaoyan WU, Jiawei XU, Runming JIN

《医学前沿（英文）》 2009年 第3卷 第1期   页码 61-66 doi: 10.1007/s11684-009-0007-8

摘要： The aim of this study was to explore the regulatory mechanism of retinoic acid (RA) on the TBX1 gene expression in myocardial cells. Ventricular cardiocytes were isolated from neonatal rats and cultured, and then treated with different concentrations of retinoic acid. The expression of Shh and Fgf8 at mRNA and protein levels in neonatal rat myocardial cells were measured by using RT-PCR and Western blot technique, respectively. There was basal expression of Shh and Fgf8 in the control group. When treated with 3×10 mol/L RA, we observed that the expression of Shh mRNA and protein in neonatal rat myocardial cells were up-regulated by 1.51 ( <0.05) and 1.10 times ( <0.05), respectively. In comparison with the control group, under the concentration of 5×10 mol/L RA, they were up-regulated by 2.21 ( <0.05) and 2.38 times ( <0.05) individually. Meanwhile, we could detect that the expression of Fgf8 mRNA and protein were up-regulated by 2.50 times ( <0.05) and 80% ( <0.05) separately compared with the control group after stimulation of 3×10 mol/L RA, and they were up-regulated by 3.48 ( <0.05) and 2.04 times ( <0.05) individually after stimulation of 5×10 mol/L RA. The results indicated that RA could induce the expression of Shh and Fgf8 in neonatal rat myocardial cells. At the same time, it has shown that Shh and Fgf8 were involved in the regulation process of RA on TBX1 expression.

关键词： retinoic acid     Tbx1 protein     Shh protein     Fgf8 protein    

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Assessment of global and regional left ventricular twist and displacement in anterior myocardial infarction

Wei HAN MM, Ming-Xing XIE MD, Qing LV MD, Xin-Fang WANG MD, Li ZHANG MM,

《医学前沿（英文）》 2010年 第4卷 第1期   页码 71-76 doi: 10.1007/s11684-010-0006-9

摘要： The recent development of 2-dimensional strain (2D strain) imaging can provide a powerful alternative for assessing left ventricular (LV) torsion. This study was conducted to evaluate the global and regional left ventricular twist by 2D strain in patients with anterior wall myocardial infarction (AMI). A total of 55 AMI patients were divided into two groups according to their ejection fraction (EF) values (group A: LVEF≥50%; group B: LVEF<50%), and 35 normal people served as the control group. Using 2-dimensional strain software, global and regional LV rotation and displacement were obtained at two planes. Compared with the control group, patients of group A showed reduced peak LV twist of the anterior and anterior-septal wall (9.26±1.89 10.74±2.67; 9.71±1.71 11.36±2.29, both <0.05), but the radial displacement and global twist were maintained (>0.05). Differently, regional and global LV twist and radial displacement in patients of group B deceased significantly, especially in the anterior and anterior-septal wall, as compared with patients in the control or group A (both <0.05). Moreover, a strong correlation was noted between peak twist and radial displacement; the twist-displacement loop was markedly distorted in patients of group B. This study demonstrated that 2D strain has a potential ability for quantification of left ventricular global and segment twist and radial displacement in patients with coronary artery disease.

关键词： echocardiography     twist     two-dimensional strain imaging     coronary artery disease    

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Buxu Tongyu Granule Alleviates Myocardial Ischemia by Activating Vascular Smooth Muscle Cell Soluble

Shuang Yang,Yixiu Zhao,Xiaoling Cheng,Tingting Zhan,Jiaying Tian,Xue Liu,Chunyue Ma,Zhiqi Wang,Luying Jin,Qian Liu,Yanli Wang,Jian Huang,Jinhui Wang,Yan Zhang,Baofeng Yang,

《工程（英文）》 doi: 10.1016/j.eng.2023.06.009

摘要： Myocardial ischemia is a serious threat to human health, and vascular dysfunction is its main cause. Buxu Tongyu Granule (BXTY) is an effective traditional Chinese medicine (TCM) for treating myocardial ischemia. However, the underlying mechanism of BXTY is still unclear. In this study, we demonstrate that BXTY ameliorates myocardial ischemia by activating the soluble guanylate cyclase (sGC)–3′,5′-cyclic guanosine monophosphate (cGMP)–protein kinase G (PKG) signaling pathway in vascular smooth muscle cells (VSMCs) to dilate the arteries. BXTY was given by gavage for ten consecutive days before establishing an animal model of acute myocardial ischemia in mice via the intraperitoneal injection of pituitrin. The results showed that BXTY alleviated the symptoms of myocardial ischemia induced by pituitrin in mice, including electrocardiogram abnormalities and changes in plasma enzymes. In addition, BXTY dilated pre-constricted blood vessels and inhibited the vasoconstriction of the superior mesenteric artery in a dose-dependent but endothelial-independent manner. These effects were eliminated by pre-incubating vascular rings with the sGC inhibitors NS 2028 or ODQ, or with the PKG inhibitor KT 5823. Moreover, BXTY increased the protein expression of sGC-β1 and the intracellular second messenger cGMP level in mouse aortic vascular smooth muscle cells (MOVAs). NS 2028 or ODQ reversed these effects of BXTY. The expression level of the cGMP downstream effector protein PKG-1 increased after treating MOVAs with BXTY. NS 2028, ODQ, or KT 5823 also reversed this effect of BXTY. In conclusion, BXTY can improve the symptoms of acute myocardial ischemia in mice, and activating the sGC–cGMP–PKG pathway in VSMCs to induce vasodilation is its key pharmacodynamic mechanism.

关键词： Myocardial ischemia     Vasomotion     Soluble guanylate cyclase     Buxu Tongyu Granule    

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Influence of freeze–thaw damage gradient on stress–strain relationship of stressed concrete

《结构与土木工程前沿（英文）》   页码 1326-1340 doi: 10.1007/s11709-023-0014-x

摘要： Influence of freeze–thaw damage gradient on stress–strain relationship of stressed concrete

关键词： strain relationship concrete    

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High velocity impact of metal sphere on thin metallic plate using smooth particle hydrodynamics (SPH)

Hossein ASADI KALAMEH, Arash KARAMALI, Cosmin ANITESCU, Timon RABCZUK

《结构与土木工程前沿（英文）》 2012年 第6卷 第2期   页码 101-110 doi: 10.1007/s11709-012-0160-z

摘要： The modeling of high velocity impact is an important topic in impact engineering. Due to various constraints, experimental data are extremely limited. Therefore, detailed numerical simulation can be considered as a desirable alternative. However, the physical processes involved in the impact are very sophisticated; hence a practical and complete reproduction of the phenomena involves complicated numerical models. In this paper, we present a smoothed particle hydrodynamics (SPH) method to model two-dimensional impact of metal sphere on thin metallic plate. The simulations are applied to different materials (Aluminum, Lead and Steel); however the target and projectile are formed of similar metals. A wide range of velocities (300, 1000, 2000, and 3100 m/s) are considered in this study. The goal is to study the most sensitive input parameters (impact velocity and plate thickness) on the longitudinal extension of the projectile, penetration depth and damage crater.

关键词： smoothed particle hydrodynamics     high velocity impact     sensitivity analysis    

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标题 作者 时间 类型 操作

Challenges and opportunities in improving left ventricular remodelling and clinical outcome following surgical and trans-catheter aortic valve replacement

期刊论文

Study on damping properties of magnetorheological damper

ZHOU Yu-feng, CHEN Hua-ling

期刊论文

Berberine alleviates myocardial diastolic dysfunction by modulating Drp1-mediated mitochondrial fission

期刊论文

Evaluation of the effect of myocardial perfusion after percutaneous coronary intervention in coronaryartery disease by using intracoronary myocardial contrast echocardiography and two other angiographic

WANG Hong, HUANG Lan, JIN Jun, SONG Yaoming, GENG Zhaohua, YU Xuejun, QIN Jun, ZHAO Gang, GAO Yunhua, LIU Zheng

期刊论文

Three-dimensional numerical simulation of flow in trapezoidal cutthroat flumes based on FLOW-3D

Danjie RAN, Wene WANG, Xiaotao HU

期刊论文

failure and left ventricular systolic dysfunction in non-diabetic patients with ST-segment elevation myocardial

Hui Wang, Yang Zhang, Zhujun Shen, Ligang Fang, Zhenyu Liu, Shuyang Zhang

期刊论文

柱形地形上单浮体的辐射和散射问题

吴必军,郑永红,游亚戈,孙晓燕,陈勇

期刊论文

Protective effect of tanshinone II A on signal transduction system protein kinase B in rats with myocardial

Enyuan TU MD, Yongjun PAN MM, Kang ZHENG MM, Zhaohua WANG MD, Qiansheng LIANG MD, Guangtian YANG MD,

期刊论文

Prediction of the shear wave velocity

Amoroso SARA

期刊论文

Modeling limit force capacities of high force to volume lead extrusion dampers

期刊论文

Influence of retinoic acid on TBX1 expression in myocardial cells induced by Shh and Fgf8

Miao LIU, Xiaoyan WU, Jiawei XU, Runming JIN

期刊论文

Assessment of global and regional left ventricular twist and displacement in anterior myocardial infarction

Wei HAN MM, Ming-Xing XIE MD, Qing LV MD, Xin-Fang WANG MD, Li ZHANG MM,

期刊论文

Buxu Tongyu Granule Alleviates Myocardial Ischemia by Activating Vascular Smooth Muscle Cell Soluble

Shuang Yang,Yixiu Zhao,Xiaoling Cheng,Tingting Zhan,Jiaying Tian,Xue Liu,Chunyue Ma,Zhiqi Wang,Luying Jin,Qian Liu,Yanli Wang,Jian Huang,Jinhui Wang,Yan Zhang,Baofeng Yang,

期刊论文

Influence of freeze–thaw damage gradient on stress–strain relationship of stressed concrete

期刊论文

High velocity impact of metal sphere on thin metallic plate using smooth particle hydrodynamics (SPH)

Hossein ASADI KALAMEH, Arash KARAMALI, Cosmin ANITESCU, Timon RABCZUK

期刊论文